PrEP is a highly effective biomedical intervention that prevents HIV. Despite the established association between HIV risk and substance use, PrEP access as well as uptake and persistence among persons with substance use disorders remains low. To fully realize HIV prevention efforts across health systems, and as substance use/healthcare-seeking patterns evolve with COVID-19, person-centered PrEP service delivery needs to involve renewed and coordinated efforts involving substance use treatment providers. This webinar helped clinicians overcome PrEP implementation challenges, assess PrEP eligibility, and identify strategies for addressing side effect and adherence concerns.