The Organizational Responsibilities SAFER Guide identifies individual and organizational responsibilities (activities, processes, and tasks) intended to optimize the safety and safe use of EHRs. A key addition to this revised guide relates to the use of Artificial Intelligence (AI)*- enabled systems, or EHRs with enhanced AI features or functions for the administration, diagnosis, treatment, and management of patient care. Such AI-enabled systems have the potential to revolutionize administrative and clinical decision-making, but there are known and unknown risks associated with their use.

This guide, compared to all of the other SAFER Guides, focuses chiefly on human behavior and relationships. In particular, it includes the structures, processes and outcomes that apply to the people who have responsibility for EHR-related patient safety in healthcare organizations.