The High Priority Practices SAFER Guide includes 16 recommendations selected from the other seven guides because of their relevance and importance for practicing clinicians to understand and support.

The 2024 revision of the High-Priority SAFER guide includes many new recommendations. One focuses on the safe and effective use of artificial intelligence (AI)- enabled applications and another on the use of patient portals and patient-clinician communication. These relatively new features offer great promise for improvements in the delivery of safe and effective healthcare, but both have risks to patient safety that must be managed.

While each of the seven individual SAFER guides is designed to be used by a multi-disciplinary group, this High Priority Guide is for front-line clinicians.