This training explored the growing role of artificial intelligence in health center operations, with a focus on both the opportunities and risks AI presents. Topics included an overview of AI applications in clinical and administrative workflows, AI-driven cybersecurity threats facing health centers, and practical strategies for defense. There was a live demonstration of AI-powered phishing generation and detection that illustrated how attackers can use AI to craft highly convincing, targeted phishing emails — and how the same technology can be leveraged to identify and neutralize these threats in real time. The session also addressed responsible AI governance, workforce readiness, vendor risk considerations, and alignment with HIPAA, Healthcare and Public Health Cybersecurity Performance Goals, and other federal compliance frameworks relevant to health centers.